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portada Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis
Type
Physical Book
Publisher
Author
Language
English
Pages
101
Format
Paperback
ISBN13
9789811374524
Categories

Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis

Kale, Avinash (Author) · Springer · Paperback

Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis - Kale, Avinash

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Synopsis "Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis"

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

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