infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of cd4-positive t-cells. this finally results in the hosts incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the acquired immunodeficiency syndrome (aids). the book aids pathogenesis provides the reader with a complete overview of the clinical course of hiv-1 infection. it describes the clinical aspects of primary infection, the different clinical outcomes of hiv-1 infection, and strategies for anti-viral treatment. in addition, more fundamental aspects of hiv-1 infection are reviewed. these include the biology of the virus and the novel insights in aids pathogenesis. not only is the significance of an hiv-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with t-cell destruction. finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.