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portada drug metabolism and transport: molecular methods and mechanisms
Type
Physical Book
Illustrated by
Publisher
Author
Year
2010
Language
English
Pages
388
Format
Paperback
Dimensions
22.9 x 15.2 x 2.3 cm
Weight
0.59 kg.
ISBN
1617374946
ISBN13
9781617374944
Categories

drug metabolism and transport: molecular methods and mechanisms

Lawrence H. Lash (Illustrated by) · Humana · Paperback

drug metabolism and transport: molecular methods and mechanisms - Lash, Lawrence H.

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Synopsis "drug metabolism and transport: molecular methods and mechanisms"

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

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