Name: selective estrogen receptor modulators
SKU: 3620508
Price: 157.19 EUR
Availability: InStock
ISBN: 9780896039124

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portada selective estrogen receptor modulators

Type

Physical Book

Publisher

Springer

Language

English

Pages

384

ISBN

0896039129

ISBN13

9780896039124

Synopsis "selective estrogen receptor modulators"

experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of serms. the basic science chapters of the book focus-with an eye to the development of the ideal serm-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. the clinical presentation reviews the data accumulated on currently available serms, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. a tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

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