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portada SIGMA Receptors: Their Role in Disease and as Therapeutic Targets
Type
Physical Book
Publisher
Author
Language
English
Pages
312
Format
Hardcover
Dimensions
26.5 x 18.7 x 2.4 cm
Weight
0.94 kg.
ISBN13
9783319501727
Categories

SIGMA Receptors: Their Role in Disease and as Therapeutic Targets

Smith, Sylvia B. ; Su, Tsung-Ping (Author) · Springer · Hardcover

SIGMA Receptors: Their Role in Disease and as Therapeutic Targets - Smith, Sylvia B. ; Su, Tsung-Ping

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Synopsis "SIGMA Receptors: Their Role in Disease and as Therapeutic Targets"

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It's putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

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