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portada Solid self-emulsifying drug delivery system
Type
Physical Book
Author
Publisher
Language
English
Pages
112
Format
Paperback
Dimensions
22.9 x 15.2 x 0.7 cm
Weight
0.18 kg.
ISBN13
9786202522830
Categories

Solid self-emulsifying drug delivery system

Priyanka Shelake (Author) · Vidya Nalawade (Author) · Priyanka Majalekar (Author) · LAP Lambert Academic Publishing · Paperback

Solid self-emulsifying drug delivery system - Shelake, Priyanka ; Nalawade, Vidya ; Majalekar, Priyanka

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Synopsis "Solid self-emulsifying drug delivery system"

In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of Mirtazapine (tetracyclic anti-depressant BCS class II drug with a low oral bioavailability of 50% ) to improve its solubility with a view to enhance its oral bioavailability. The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by adsorption technique by using as Neusiline US2 solid carrier. The formulation was evaluated for various tests such as solubility, drug content, emulsification time, phase separation study, dispersibility test, droplet size analysis and PDI determination and zeta potential and in-vitro release study, and in-vitro permeation study.

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