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portada Study on in Vitro
Type
Physical Book
Publisher
Author
Year
2015
Language
English
Pages
192
Format
Paperback
ISBN13
9783639819106

Study on in Vitro

Yuh-Tyng Huang (Author) · · Paperback

Study on in Vitro - Yuh-Tyng Huang

New Book Imported to Netherlands
Delivery: 09 Oct - 13 Oct Shipping: 14 to 15 business days.
€ 149,68
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Synopsis "Study on in Vitro "

Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms that were developed by extrusion-spheronization, direct compression and fluid-bed methods. Produced by the aforementioned methods, the optimal PB-SR dosage forms could improve the hygroscopic defect of PB and reach the SR effect. In vivo study, a good linear regression relationship was observed between the fraction dissolution and fraction absorption for the optimal PB-SR dosage forms. However, the results of microdialysis technique shown that the release of acetylcholine and the release of protein unbound drug for the PB-SR pellets provided with SR effect in vivo as well.

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