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portada cell immortalization
Type
Physical Book
Illustrated by
Publisher
Author
Year
2010
Language
English
Pages
208
Format
Paperback
Dimensions
23.4x15.6x1.2 cm
Weight
0.31 kg.
ISBN
3642084915
ISBN13
9783642084911
Categories

cell immortalization

Alvaro Macieira-Coelho (Illustrated by) · Springer · Paperback

cell immortalization - Macieira-Coelho, Alvaro

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Synopsis "cell immortalization"

The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera- tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim- ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris- ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera- tive phenotypes has to be seen using the perspective of comparative biology.

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