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portada Floating Microspheres
Type
Physical Book
Publisher
Author
Language
English
Pages
160
Format
Paperback
ISBN13
9783659327278

Floating Microspheres

Supriya Muttepawar (Author) · Lap Lambert Academic Publishing · Paperback

Floating Microspheres - Supriya Muttepawar

New Book Imported to Netherlands
Delivery: 21 Oct - 23 Oct Shipping: 13 to 14 business days.
€ 296,78
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€ 296,78

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Synopsis "Floating Microspheres"

Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the 'all-or-none' gastric emptying nature of single unit systems. A type of multi-unit floating ziprasidone HCL Monohydrate microspheres was prepared by the ionotropic gelation method with NaHCO3 as gas-forming agents being used as gas-forming agent and Eudragit L-100 and Eudragit S-100 as polymer. The solution was dropped to 1% CaCl2 solution containing 10% acetic acid for CO2 gas and gel formation. The effects of gas-forming agents on bead size and floating properties were investigated. As gas-forming agents increased, the size and floating properties increased. Bead porosity and volume average pore size, as well as the surface and cross-sectional morphology of the beads were examined with Scanning Electron Microscopy. The micromeritic properties of microspheres were found to be much improved. In-vitro drug release studies were performed and drug release kinetics were evaluated using the linear regression method.

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