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portada genomic imprinting
Type
Physical Book
Illustrated by
Publisher
Author
Year
2010
Language
English
Pages
126
Format
Paperback
Dimensions
25.4x17.8x0.8 cm
Weight
0.26 kg.
ISBN
1441926585
ISBN13
9781441926586
Categories

genomic imprinting

Jon F. Wilkins (Illustrated by) · Springer · Paperback

genomic imprinting - Wilkins, Jon F.

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Synopsis "genomic imprinting"

Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles. These epigenetic differences include DNA methylation at CpG dinucleotides, as well as modifications on the histones associated with the locus. In the simplest possible cases, the promoter region of the imprinted gene is methylated during oogenesis, but not spermatogenesis (or vice versa). This methylation (and its accompanying histone modifications) results in inactivation of the modified allele. Of course, most imprinted genes do not fall into this simplest case. The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field (which would necessarily span multiple books). Rather, the book covers on some of the more recent advances, with the goal of drawing attention to some of the emerging subtleties and complexities associated with imprinted genes.

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